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📄 ResearchMay 13, 2026

Structured large language model extraction of clinical factors from electronic health record text supports scalable psychiatric severity prediction

Background: Mental health systems face escalating demand that exceeds clinician capacity, making accurate severity-based triage a critical bottleneck. Severity assessment guides treatment intensity, resource allocation, and risk management, yet most clinically relevant information remains embedded in unstructured electronic health record (EHR) narratives, limiting its utility for scalable decision support. Objectives: This study evaluates whether a single large language model (LLM) can autonomously extract clinical factors from psychiatric EHR narratives, derive predictive weights from those factors, and use the resulting structured representation to predict clinician-implied severity at scale. Methods: From a Mayo Clinic repository of more than 2.7 million encounters, 15,000 de-identified psychiatric notes were sampled into a 5,000-patient discovery cohort and a 10,000-patient replication cohort. The same LLM (Llama 3 8B Instruct) extracted 17 background clinical factors and 3 treatme

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Source

https://www.medrxiv.org/content/10.64898/2026.05.11.26352839v1?rss=1